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Your query returned 1 entry. 
Printable version
| EC | 1.14.20.8 | ||
| Accepted name: | (–)-deoxypodophyllotoxin synthase | ||
| Reaction: | (–)-yatein + 2-oxoglutarate + O2 = (–)-deoxypodophyllotoxin + succinate + CO2 + H2O | ||
| For diagram of podophyllotoxin biosynthesis, click here | |||
| Glossary: | (–)-yatein = (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzyl)dihydrofuran-2(3H)-one (–)-deoxypodophyllotoxin = (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d][1,3]dioxol-6(5a)-one |
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| Other name(s): | 2-ODD (gene name) | ||
| Systematic name: | (–)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming) | ||
| Comments: | The enzyme, characterized from the plant Sinopodophyllum hexandrum (mayapple), is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold. | ||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||
| References: |
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