The Enzyme Database

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Accepted name: all-trans-retinol 3,4-desaturase
Reaction: all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2 = all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O
For diagram of retinal and derivatives biosynthesis, click here
Other name(s): CYP27C1 (gene name)
Systematic name: all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase
Comments: A cytochrome P-450 (heme thiolate) enzyme found in vertebrates. The enzyme is also active with retinal and retinoic acid.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Enright, J.M., Toomey, M.B., Sato, S.Y., Temple, S.E., Allen, J.R., Fujiwara, R., Kramlinger, V.M., Nagy, L.D., Johnson, K.M., Xiao, Y., How, M.J., Johnson, S.L., Roberts, N.W., Kefalov, V.J., Guengerich, F.P. and Corbo, J.C. Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting vitamin A1 into A2. Curr. Biol. 25 (2015) 3048–3057. [DOI] [PMID: 26549260]
2.  Kramlinger, V.M., Nagy, L.D., Fujiwara, R., Johnson, K.M., Phan, T.T., Xiao, Y., Enright, J.M., Toomey, M.B., Corbo, J.C. and Guengerich, F.P. Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids. FEBS Lett. 590 (2016) 1304–1312. [DOI] [PMID: 27059013]
[EC created 2018]

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