EC	1.14.15.4
Accepted name:	steroid 11β-monooxygenase
Reaction:	a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11β-hydroxysteroid + 2 oxidized adrenodoxin + H2O
Other name(s):	steroid 11β-hydroxylase; steroid 11β/18-hydroxylase
Systematic name:	steroid,reduced-adrenodoxin:oxygen oxidoreductase (11β-hydroxylating)
Comments:	A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
References:	1.  Grant, J.K. and Brownie, A.C. The role of fumarate and TPN in steroid enzymic 11β-hydroxylation. Biochim. Biophys. Acta 18 (1955) 433–434. [PMID: 13276417] 2.  Hayano, M. and Dorfman, R.I. On the mechanism of the C-11β-hydroxylation of steroids. J. Biol. Chem. 211 (1954) 227–235. [PMID: 13211659] 3.  Tomkins, G.M., Michael, P.J. and Curran, J.F. Studies on the nature of steroid 11-β hydroxylation. Biochim. Biophys. Acta 23 (1957) 655–656. [PMID: 13426185] 4.  Yanagibashi, K., Haniu, M., Shively, J.E., Shen, W.H. and Hall, P. The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldehyde synthesis. J. Biol. Chem. 261 (1986) 3556–3562. [PMID: 3485096] 5.  Zuidweg, M.H.J. Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata. Biochim. Biophys. Acta 152 (1968) 144–158. [PMID: 4967077]
[EC 1.14.15.4 created 1961 as EC 1.99.1.7, transferred 1965 to EC 1.14.1.6, transferred 1972 to EC 1.14.15.4, modified 1989, modified 2014]