| EC |
1.14.14.26 |
| Accepted name: |
24-hydroxycholesterol 7α-hydroxylase |
| Reaction: |
(24S)-cholest-5-ene-3β,24-diol + [reduced NADPH—hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3β,7α,24-triol + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of cholesterol catabolism (rings a, B and c), click here |
| Glossary: |
(24S)-cholest-5-ene-3β,24-diol = (24S)-24-hydroxycholesterol |
| Other name(s): |
24-hydroxycholesterol 7α-monooxygenase; CYP39A1; CYP39A1 oxysterol 7α-hydroxylase |
| Systematic name: |
(24S)-cholest-5-ene-3β,24-diol,NADPH—hemoprotein reductase:oxygen oxidoreductase (7α-hydroxylating) |
| Comments: |
A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3β,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 288309-90-0 |
| References: |
| 1. |
Li-Hawkins, J., Lund, E.G., Bronson, A.D. and Russell, D.W. Expression cloning of an oxysterol 7α-hydroxylase selective for 24-hydroxycholesterol. J. Biol. Chem. 275 (2000) 16543–16549. [DOI] [PMID: 10748047] |
| 2. |
Ikeda, H., Ueda, M., Ikeda, M., Kobayashi, H. and Honda, Y. Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye. Lab. Invest. 83 (2003) 349–355. [PMID: 12649335] |
| 3. |
Russell, D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 72 (2003) 137–174. [DOI] [PMID: 12543708] |
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| [EC 1.14.14.26 created 2005 as EC 1.14.13.99, transferred 2016 to EC 1.14.14.26] |
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