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Your query returned 1 entry. Printable version
EC | 1.14.14.25 | ||||||||||
Accepted name: | cholesterol 24-hydroxylase | ||||||||||
Reaction: | cholesterol + [reduced NADPH—hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3β,24-diol + [oxidized NADPH—hemoprotein reductase] + H2O | ||||||||||
For diagram of cholic acid biosynthesis (sidechain), click here | |||||||||||
Glossary: | cholesterol = cholest-5-en-3β-ol (24S)-24-hydroxycholesterol = (24S)-cholest-5-ene-3β,24-diol |
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Other name(s): | cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1 | ||||||||||
Systematic name: | cholesterol,NADPH—hemoprotein reductase:oxygen oxidoreductase (24-hydroxylating) | ||||||||||
Comments: | A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood—brain barrier whereas cholesterol cannot [3]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase [3]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 50812-30-1, 213327-78-7 | ||||||||||
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