| EC |
1.14.14.193 |
| Accepted name: |
taxol side chain-2′-hydroxylase |
| Reaction: |
3′-N-debenzoyl-2′-deoxytaxol + [reduced NADPH-hemoprotein reductase] + O2 = 3′-N-debenzoyltaxol + [oxidized NADPH-hemoprotein reductase] + H2O |
| Other name(s): |
CYP73A171; T2'OH; TB506 |
| Systematic name: |
3′-N-debenzoyl-2′-deoxytaxol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (2′-hydroxylating) |
| Comments: |
A cytochrome-P-450 (heme thiolate) enzyme isolated from the plant Taxus × media. The penultimate step in paclitaxel (taxol) biosynthesis. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Sanchez-Munoz, R., Perez-Mata, E., Almagro, L., Cusido, R.M., Bonfill, M., Palazon, J. and Moyano, E. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol 8:410 (2020). [DOI] [PMID: 32528936] |
| 2. |
Long, R.M. and Croteau, R. Preliminary assessment of the C13-side chain 2′-hydroxylase involved in taxol biosynthesis. Biochem. Biophys. Res. Commun. 338 (2005) 410–417. [DOI] [PMID: 16137660] |
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| [EC 1.14.14.193 created 2025] |
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