| EC |
1.14.14.189 |
| Accepted name: |
strychnine 10-hydroxylase |
| Reaction: |
strychnine + [reduced NADPH—hemoprotein reductase] + O2 = 10-hydroxystrychnine + [oxidized NADPH—hemoprotein reductase] + H2O |
| Glossary: |
strychnine = (4bR,4b1S,7aS,8aR,8a1R,12aS)-4b1,5,6,7a,8,8a,8a1,11,12a,13-decahydro-14H-12-oxa-7,14a-diaza-7,9-methanocyclohepta[cd]cyclopenta[g]fluoranthen-14-one |
| Other name(s): |
CYP82D36 |
| Systematic name: |
strychnine,[NADPH—hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating) |
| Comments: |
A cytochrome P-450 (heme-thiolate) protein. The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617–622. [DOI] [PMID: 35794473] |
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| [EC 1.14.14.189 created 2024] |
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