The Enzyme Database

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Accepted name: geranylhydroquinone 3′′-hydroxylase
Reaction: geranylhydroquinone + [reduced NADPH—hemoprotein reductase] + O2 = 3′′-hydroxygeranylhydroquinone + [oxidized NADPH—hemoprotein reductase] + H2O
Glossary: 3′′-hydroxygeranylhydroquinone = 2-[(2Z)-3-(hydroxymethyl)-7-methylocta-2,6-dien-1-yl]benzene-1,4-diol
Other name(s): GHQ 3′′-hydroxylase; CYP76B74 (gene name); geranylhydroquinone,NADPH:oxygen oxidoreductase (3′′-hydroxylating)
Systematic name: geranylhydroquinone,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (3′′-hydroxylating)
Comments: A cytochrome P-450 (heme-thiolate) protein found in plants, where it is part of the biosynthesis pathway of the red naphthoquinone pigment shikonin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Yamamoto, H., Inoue, K., Li, S.M. and Heide, L. Geranylhydroquinone 3′′-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures. Planta 210 (2000) 312–317. [DOI] [PMID: 10664138]
2.  Wang, S., Wang, R., Liu, T., Lv, C., Liang, J., Kang, C., Zhou, L., Guo, J., Cui, G., Zhang, Y., Werck-Reichhart, D., Guo, L. and Huang, L. CYP76B74 catalyzes the 3′′-hydroxylation of geranylhydroquinone in shikonin biosynthesis. Plant Physiol. 179 (2019) 402–414. [PMID: 30498024]
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