The Enzyme Database

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Accepted name: leukotriene-E4 20-monooxygenase
Reaction: (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + H+ + O2 = 20-hydroxyleukotriene E4 + NADP+ + H2O
Other name(s): leukotriene-E4 ω-hydroxylase
Systematic name: (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
Comments: Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC leukotriene-B4 20-monooxygenase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 111940-51-3
1.  Örning, L. ω-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of ω-hydroxy and ω-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4. Eur. J. Biochem. 170 (1987) 77–85. [PMID: 2826163]
[EC created 1989]

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