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Your query returned 1 entry. Printable version
EC | 1.14.13.248 | ||||
Accepted name: | L-aspartate N-monooxygenase (nitrosuccinate-forming) | ||||
Reaction: | L-aspartate + 3 NADPH + 3 H+ + 3 O2 = (2S)- 2-nitrobutanedioate + 3 NADP+ + 4 H2O (1a) L-aspartate + NADPH + H+ + O2 = N-hydroxy-L-aspartate + NADP+ + H2O (1b) N-hydroxy-L-aspartate + NADPH + H+ + O2 = N,N-dihydroxy-L-aspartate + NADP+ + H2O (1c) N,N-dihydroxy-L-aspartate = (2S)-2-nitrosobutanedioate + H2O (spontaneous) (1d) (2S)-2-nitrosobutanedioate + NADPH + H+ + O2 = (2S)-2-nitrobutanedioate + NADP+ + H2O |
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Glossary: | 2-nitrobutanedioate = nitrosuccinate | ||||
Other name(s): | creE (gene name) | ||||
Systematic name: | L-aspartate,NADPH:oxygen oxidoreductase [(2S)-2-nitrobutanedioate-forming] | ||||
Comments: | The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites. Requires an FAD cofactor. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
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