The Enzyme Database

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Accepted name: assimilatory dimethylsulfide S-monooxygenase
Reaction: (1) dimethyl sulfide + NADH + H+ + O2 = dimethyl sulfoxide + NAD+ + H2O
(2) dimethyl sulfoxide + NADH + H+ + O2 = dimethyl sulfone + NAD+ + H2O
For diagram of dimethyl sulfide catabolism, click here
Other name(s): dsoBCDEF (gene names)
Systematic name: dimethyl sulfide,NADH:oxygen oxidoreductase (S-oxidizing)
Comments: The enzyme, studied from the bacterium Acinetobacter sp. strain 20B, is very similar to EC, phenol 2-monooxygenase (NADH). It consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The three components comprise five different polypeptides. The enzyme catalyses the first two steps of a dimethyl sulfide oxidation pathway in this organism.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Horinouchi, M., Kasuga, K., Nojiri, H., Yamane, H. and Omori, T. Cloning and characterization of genes encoding an enzyme which oxidizes dimethyl sulfide in Acinetobacter sp. strain 20B. FEMS Microbiol. Lett. 155 (1997) 99–105. [PMID: 9345770]
2.  Horinouchi, M., Yoshida, T., Nojiri, H., Yamane, H. and Omori, T. Polypeptide requirement of multicomponent monooxygenase DsoABCDEF for dimethyl sulfide oxidizing activity. Biosci. Biotechnol. Biochem. 63 (1999) 1765–1771. [PMID: 26300166]
[EC created 2019]

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