The Enzyme Database

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Accepted name: protoasukamycin 4-monooxygenase
Reaction: protoasukamycin + NADH + H+ + O2 = 4-hydroxyprotoasukamycin + NAD+ + H2O
Glossary: asuE1 (gene name)
Systematic name: protoasukamycin,NADH:oxygen oxidoreductase (4-hydroxylating)
Comments: The enzyme, characterized from the bacterium Streptomyces nodosus subsp. asukaensis, is involved in the biosynthesis of the antibiotic asukamycin. Requires a flavin cofactor, with no preference among FMN, FAD or riboflavin. When flavin concentration is low, activity is enhanced by the presence of the NADH-dependent flavin-reductase AsuE2.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Rui, Z., Sandy, M., Jung, B. and Zhang, W. Tandem enzymatic oxygenations in biosynthesis of epoxyquinone pharmacophore of manumycin-type metabolites. Chem. Biol. 20 (2013) 879–887. [DOI] [PMID: 23890006]
[EC created 2016]

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