The Enzyme Database

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Accepted name: 6-hydroxy-3-succinoylpyridine 3-monooxygenase
Reaction: 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
Glossary: 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate = 6-hydroxy-3-succinoyl-pyridine
Other name(s): 6-hydroxy-3-succinoylpyridine hydroxylase; hspA (gene name); hspB (gene name)
Systematic name: 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)
Comments: The enzyme catalyses a reaction in the nicotine degradation pathway of Pseudomonas species. One of the enzymes from the soil bacterium Pseudomonas putida S16 contains an FAD cofactor [2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Tang, H., Wang, S., Ma, L., Meng, X., Deng, Z., Zhang, D., Ma, C. and Xu, P. A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16. Appl. Environ. Microbiol. 74 (2008) 1567–1574. [DOI] [PMID: 18203859]
2.  Tang, H., Yao, Y., Zhang, D., Meng, X., Wang, L., Yu, H., Ma, L. and Xu, P. A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida. J. Biol. Chem. 286 (2011) 39179–39187. [DOI] [PMID: 21949128]
[EC created 2012]

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