| EC |
1.14.13.149 |
| Accepted name: |
phenylacetyl-CoA 1,2-epoxidase |
| Reaction: |
phenylacetyl-CoA + NADPH + H+ + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O |
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For diagram of aerobic phenylacetate catabolism, click here |
| Glossary: |
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-{7-oxabicyclo[4.1.0]hepta-2,4-dien-1-yl}acetyl-CoA |
| Other name(s): |
ring 1,2-phenylacetyl-CoA epoxidase; phenylacetyl-CoA monooxygenase; PaaAC; PaaABC(D)E |
| Systematic name: |
phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing) |
| Comments: |
Part of the aerobic pathway of phenylacetate catabolism in Escherichia coli and Pseudomonas putida. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc. Natl. Acad. Sci. USA 107 (2010) 14390–14395. [DOI] [PMID: 20660314] |
| 2. |
Grishin, A.M., Ajamian, E., Zhang, L. and Cygler, M. Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (2010) 1045–1049. [DOI] [PMID: 20823522] |
| 3. |
Grishin, A.M., Ajamian, E., Tao, L., Zhang, L., Menard, R. and Cygler, M. Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. J. Biol. Chem. 286 (2011) 10735–10743. [DOI] [PMID: 21247899] |
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| [EC 1.14.13.149 created 2012] |
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