| EC |
1.14.13.146 |
| Accepted name: |
taxoid 14β-hydroxylase |
| Reaction: |
10β-hydroxytaxa-4(20),11-dien-5α-yl acetate + O2 + NADPH + H+ = 10β,14β-dihydroxytaxa-4(20),11-dien-5α-yl acetate + NADP+ + H2O |
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For diagram of taxadiene hydroxylation, click here |
| Systematic name: |
10β-hydroxytaxa-4(20),11-dien-5α-yl-acetate,NADPH:oxygen 14-oxidoreductase |
| Comments: |
Requires cytochrome P450. From the yew Taxus cuspidata. Also acts on taxa-4(20),11-dien-5α-yl acetate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Jennewein, S., Rithner, C.D., Williams, R.M. and Croteau, R. Taxoid metabolism: Taxoid 14β-hydroxylase is a cytochrome P450-dependent monooxygenase. Arch. Biochem. Biophys. 413 (2003) 262–270. [DOI] [PMID: 12729625] |
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| [EC 1.14.13.146 created 2012] |
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