| EC |
1.14.12.17 |
| Accepted name: |
nitric oxide dioxygenase |
| Reaction: |
2 nitric oxide + 2 O2 + NAD(P)H = 2 nitrate + NAD(P)+ + H+ |
| Glossary: |
nitric oxide = NO = nitrogen(II) oxide |
| Systematic name: |
nitric oxide,NAD(P)H:oxygen oxidoreductase |
| Comments: |
A flavohemoglobin (FAD). It has been proposed that FAD functions as the electron carrier from NADPH to the ferric heme cofactor |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 214466-78-1 |
| References: |
| 1. |
Gardner, P.R., Costantino, G. and Salzman, A.L. Constitutive and adaptive detoxification of nitric oxide in Escherichia coli. Role of nitric-oxide dioxygenase in the protection of aconitase. J. Biol. Chem. 273 (1998) 26528–26533. [DOI] [PMID: 9756889] |
| 2. |
Gardner, P.R., Gardner, A.M., Martin, L.A. and Salzman, A.L. Nitric oxide dioxygenase: an enzymic function for flavohemoglobin. Proc. Natl. Acad. Sci. USA 95 (1998) 10378–10383. [DOI] [PMID: 9724711] |
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| [EC 1.14.12.17 created 2000] |
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