ExplorEnz: EC 1.14.11.51

Your query returned 1 entry. Printable version

1.14.11.51

Accepted name:

DNA N⁶-methyladenine demethylase

Reaction:

N⁶-methyladenine in DNA + 2-oxoglutarate + O₂ = adenine in DNA + formaldehyde + succinate + CO₂

Other name(s):

ALKBH1

Systematic name:

DNA-N⁶-methyladenosine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)

Comments:

Contains iron(II). Catalyses oxidative demethylation of DNA N⁶-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

Wu, T.P., Wang, T., Seetin, M.G., Lai, Y., Zhu, S., Lin, K., Liu, Y., Byrum, S.D., Mackintosh, S.G., Zhong, M., Tackett, A., Wang, G., Hon, L.S., Fang, G., Swenberg, J.A. and Xiao, A.Z. DNA methylation on N-adenine in mammalian embryonic stem cells. Nature 532 (2016) 329–333. [DOI] [PMID: 27027282]

[EC 1.14.11.51 created 2016]