| EC |
1.14.11.32 |
| Accepted name: |
codeine 3-O-demethylase |
| Reaction: |
codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + CO2 |
| Other name(s): |
codeine O-demethylase; CODM |
| Systematic name: |
codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating) |
| Comments: |
Requires Fe2+. Catalyses a step in morphine biosynthesis. The enzyme also catalyses the 3-O-demethylation of thebaine to oripavine, with lower efficiency. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Hagel, J.M. and Facchini, P.J. Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. Nat. Chem. Biol. 6 (2010) 273–275. [DOI] [PMID: 20228795] |
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| [EC 1.14.11.32 created 2010] |
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