The Enzyme Database

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Accepted name: 7,8-dihydroneopterin oxygenase
Reaction: 7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde
For diagram of methanopterin biosynthesis (part 1), click here
Glossary: 7,8-dihydroneopterin = 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydropteridin-4(3H)-one
7,8-dihydroxanthopterin = 2-amino-3,5,7,8-tetrahydropteridin-4,6-dione
Systematic name: 7,8-dihydroneopterin:oxygen oxidoreductase
Comments: The enzyme from the bacterium Mycobacterium tuberculosis is multifunctional and also catalyses the epimerisation of the 2′-hydroxy group of 7,8-dihydroneopterin (EC, 7,8-dihydroneopterin epimerase) and the reaction of EC (dihydroneopterin aldolase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Czekster, C.M. and Blanchard, J.S. One substrate, five products: reactions catalyzed by the dihydroneopterin aldolase from Mycobacterium tuberculosis. J. Am. Chem. Soc. 134 (2012) 19758–19771. [DOI] [PMID: 23150985]
[EC created 2015]

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