The Enzyme Database

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Accepted name: all-trans-8′-apo-β-carotenal 15,15′-oxygenase
Reaction: all-trans-8′-apo-β-carotenal + O2 = all-trans-retinal + (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial
For diagram of 8′-apo-β-carotenal metabolites, click here
Other name(s): Diox1; ACO; 8′-apo-β-carotenal 15,15′-oxygenase
Systematic name: all-trans-8′-apo-β-carotenal:oxygen 15,15′-oxidoreductase (bond-cleaving)
Comments: Contains an Fe2+-4His arrangement. The enzyme is involved in retinal biosynthesis in bacteria [2].
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB
1.  Ruch, S., Beyer, P., Ernst, H. and Al-Babili, S. Retinal biosynthesis in Eubacteria: in vitro characterization of a novel carotenoid oxygenase from Synechocystis sp. PCC 6803. Mol. Microbiol. 55 (2005) 1015–1024. [DOI] [PMID: 15686550]
2.  Kloer, D.P., Ruch, S., Al-Babili, S., Beyer, P. and Schulz, G.E. The structure of a retinal-forming carotenoid oxygenase. Science 308 (2005) 267–269. [DOI] [PMID: 15821095]
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