The Enzyme Database

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Accepted name: homogentisate 1,2-dioxygenase
Reaction: homogentisate + O2 = 4-maleylacetoacetate
Other name(s): homogentisicase; homogentisate oxygenase; homogentisate dioxygenase; homogentisate oxidase; homogentisic acid oxidase; homogentisic acid oxygenase; homogentisic oxygenase; homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
Systematic name: homogentisate:oxygen 1,2-oxidoreductase (ring-opening)
Comments: Requires Fe2+.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9029-49-6
1.  Adachi, K., Iwayama, Y., Tanioka, H. and Takeda, Y. Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens. Biochim. Biophys. Acta 118 (1966) 88–97. [PMID: 5954067]
2.  Crandall, D.I. and Halikis, D.N. Homogentisic acid oxidase. I. Distribution in animal tissues and relation to tyrosine metabolism in rat kidney. J. Biol. Chem. 208 (1954) 629–638. [PMID: 13174573]
3.  Hayaishi, O. Direct oxygenation by O2, oxygenases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 8, Academic Press, New York, 1963, pp. 353–371.
4.  Kita, H., Kamimoto, M., Senoh, S., Adachi, T. and Takeda, Y. Cystallization and some properties of 3,4-dihydroxyphenylacetate-2,3-oxygenase. Biochem. Biophys. Res. Commun. 18 (1965) 66–70. [DOI] [PMID: 14265758]
5.  Knox, W.E. and Edwards, S.W. Homogentisate oxidase of liver. J. Biol. Chem. 216 (1955) 479–487. [PMID: 13271328]
6.  Ravdin, R.G. and Crandall, D.I. The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid. J. Biol. Chem. 189 (1951) 137–149. [PMID: 14832225]
[EC created 1961 as EC, transferred 1965 to EC, transferred 1972 to EC]

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