ExplorEnz: EC 1.13.11.4

1.13.11.4

Accepted name:

gentisate 1,2-dioxygenase

Reaction:

2,5-dihydroxybenzoate + O₂ = maleylpyruvate

Other name(s):

gentisate oxygenase; 2,5-dihydroxybenzoate dioxygenase; gentisate dioxygenase; gentisic acid oxidase; gentisate:oxygen 1,2-oxidoreductase (decyclizing)

Systematic name:

gentisate:oxygen 1,2-oxidoreductase (ring-opening)

Comments:

Requires Fe²⁺.

References:

1.	Hayaishi, O. Direct oxygenation by O₂, oxygenases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 8, Academic Press, New York, 1963, pp. 353–371.
2.	Sugiyama, S., Yano, K., Komagata, K. and Arima, K. Metabolites of aromatic compounds by microbes. Part VII. Gentisic acid oxidase. Bull. Agric. Chem. Soc. Jpn 24 (1960) 243–248.
3.	Sugiyama, S., Yano, K. and Arima, K. Metabolites of aromatic compounds by microbes. Part VII. Further studies of gentisic acid oxidase. Bull. Agric. Chem. Soc. Jpn 24 (1960) 249–254.

[EC 1.13.11.4 created 1961 as EC 1.99.2.4, transferred 1965 to EC 1.13.1.4, transferred 1972 to EC 1.13.11.4]