| EC |
1.11.2.8 |
| Accepted name: |
L-tryptophan 5-peroxygenase |
| Reaction: |
L-tryptophan + H2O2 = 5-hydroxy-L-tryptophan + H2O |
| Other name(s): |
luz15 (gene name); bacterial tryptophan 5-hydroxylase |
| Systematic name: |
L-tryptophan:hydrogen-peroxide 5-oxidoreductase |
| Comments: |
The enzyme from the bacterium Actinomadura luzonensis is involved in the biosynthesis of the antitumour and antiviral depsipeptide luzopeptin A. Contains a heme b cofactor. The enzyme can use O2 (and ascorbate) instead of H2O2, but the reaction with H2O2 is at least two orders of magnitude faster. cf. EC 1.14.16.4, tryptophan 5-monooxygenase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Shi, X., Zhao, G., Li, H., Zhao, Z., Li, W., Wu, M. and Du, Y.L. Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria. Nat. Chem. Biol. 19 (2023) 1415–1422. [DOI] [PMID: 37653171] |
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| [EC 1.11.2.8 created 2025] |
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