ExplorEnz: EC 1.11.2.7

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1.11.2.7

Accepted name:

torosachrysone 7,10′-coupling peroxygenase

Reaction:

2 (R)-torosachrysone + H₂O₂ = phlegmacin + 2 H₂O

Glossary:

(R)-torosachrysone = (3R)-3,8,9-trihydroxy-6-methoxy-3-methyl-3,4-dihydroanthracen-1(2H)-one
phlegmacin = 1,2′,5′,6,9,10′-hexahydroxy-3,7′-dimethoxy-2′,6-dimethyl-2′,3′,6,7-tetrahydro[2,9′-bianthracene]-4′(1'H),8(5H)-dione

Other name(s):

UPO1

Systematic name:

(R)-torosachrysone:hydrogen-peroxide oxidoreductase (phlegmacin-forming)

Comments:

The enzyme, characterized from the mushroom Calonarius odorifer, catalyses the regioselective coupling of two molecules of the phenolic compound (R)-torosachrysone at the corresponding C₇ and C₁₀′ positions, forming the 7,10′-coupled dimeric product (phlegmacin). The enzyme produces both atropisomers of the product.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Platz, L., Lohr, N.A., Girkens, M.P., Eisen, F., Braun, K., Fessner, N., Bar, C., Huttel, W., Hoffmeister, D. and Muller, M. Regioselective oxidative phenol coupling by a mushroom unspecific peroxygenase. Angew. Chem. Int. Ed. Engl. 63:e202407425 (2024). [DOI] [PMID: 38963262]

[EC 1.11.2.7 created 2025]