The Enzyme Database

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Accepted name: L-tyrosine peroxygenase
Reaction: L-tyrosine + H2O2 = L-dopa + H2O
Systematic name: L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Comments: The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC, 3-methyl-L-tyrosine peroxygenase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Neusser, D., Schmidt, H., Spizek, J., Novotna, J., Peschke, U., Kaschabeck, S., Tichy, P. and Piepersberg, W. The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A. Arch. Microbiol. 169 (1998) 322–332. [PMID: 9531633]
2.  Connor, K.L., Colabroy, K.L. and Gerratana, B. A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin. Biochemistry 50 (2011) 8926–8936. [PMID: 21919439]
[EC created 2020]

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