| EC |
1.11.2.5 |
| Accepted name: |
3-methyl-L-tyrosine peroxygenase |
| Reaction: |
3-methyl-L-tyrosine + H2O2 = 3-hydroxy-5-methyl-L-tyrosine + H2O |
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For diagram of saframycin biosynthesis, click here |
| Other name(s): |
SfmD; SacD; 3-methyltyrosine peroxidase; 3-methyl-L-tyrosine peroxidase |
| Systematic name: |
3-methyl-L-tyrosine:hydrogen-peroxide oxidoreductase (3-hydroxy-5-methyl-L-tyrosine-forming) |
| Comments: |
The heme-containing peroxygenase from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Tang, M.C., Fu, C.Y. and Tang, G.L. Characterization of SfmD as a heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis. J. Biol. Chem. 287 (2012) 5112–5121. [DOI] [PMID: 22187429] |
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| [EC 1.11.2.5 created 2014] |
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