The Enzyme Database

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Accepted name: lactate—malate transhydrogenase
Reaction: (S)-lactate + oxaloacetate = pyruvate + malate
Other name(s): malate-lactate transhydrogenase
Systematic name: (S)-lactate:oxaloacetate oxidoreductase
Comments: Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This cofactor cannot be removed without denaturation of the protein.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 9077-15-0
1.  Allen, S.H.G. The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus. J. Biol. Chem. 241 (1966) 5266–5275. [DOI] [PMID: 4289051]
2.  Allen, S.H.G. and Patil, J.R. Studies on the structure and mechanism of action of the malate-lactate transhydrogenase. J. Biol. Chem. 247 (1972) 909–916. [DOI] [PMID: 4333516]
[EC created 1972]

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