ExplorEnz: EC 1.1.5.12

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1.1.5.12

Accepted name:

D-lactate dehydrogenase (quinone)

Reaction:

(R)-lactate + a quinone = pyruvate + a quinol

Other name(s):

dld (gene name)

Systematic name:

(R)-lactate:quinone 2-oxidoreductase

Comments:

The enzyme is an FAD-dependent peripheral membrane dehydrogenase that participates in respiration. Electrons derived from D-lactate oxidation are transferred to the membrane soluble quinone pool.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Kohn, L.D. and Kaback, H.R. Mechanisms of active transport in isolated bacterial membrane vesicles. XV. Purification and properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli. J. Biol. Chem. 248 (1973) 7012–7017. [PMID: 4582730]
2.	Futai, M. Membrane D-lactate dehydrogenase from Escherichia coli. Purification and properties. Biochemistry 12 (1973) 2468–2474. [PMID: 4575624]
3.	Matsushita, K. and Kaback, H.R. D-Lactate oxidation and generation of the proton electrochemical gradient in membrane vesicles from Escherichia coli GR19N and in proteoliposomes reconstituted with purified D-lactate dehydrogenase and cytochrome o oxidase. Biochemistry 25 (1986) 2321–2327. [PMID: 3013300]
4.	Peersen, O.B., Pratt, E.A., Truong, H.T., Ho, C. and Rule, G.S. Site-specific incorporation of 5-fluorotryptophan as a probe of the structure and function of the membrane-bound D-lactate dehydrogenase of Escherichia coli: a 19^F nuclear magnetic resonance study. Biochemistry 29 (1990) 3256–3262. [PMID: 2185834]
5.	Dym, O., Pratt, E.A., Ho, C. and Eisenberg, D. The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme. Proc. Natl. Acad. Sci. USA 97 (2000) 9413–9418. [DOI] [PMID: 10944213]

[EC 1.1.5.12 created 2017]