ExplorEnz: EC 1.1.3.48

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1.1.3.48

Accepted name:

3-deoxy-α-D-manno-octulosonate 8-oxidase

Reaction:

3-deoxy-α-D-manno-octulopyranosonate + O₂ = 3,8-dideoxy-8-oxo-α-D-manno-octulosonate + H₂O₂

Glossary:

3-deoxy-α-D-manno-octulosonate = Kdo
3,8-dideoxy-8-oxo-α-D-manno-octulosonate = (2R,4R,5R,6S)-2,4,5-trihydroxy-6-[(1S)-1-hydroxy-2-oxoethyl]oxane-2-carboxylate

Other name(s):

kdnB (gene name)

Systematic name:

3-deoxy-α-D-manno-octulopyranosonate:oxygen 8-oxidoreductase

Comments:

The enzyme, characterized from the bacterium Shewanella oneidensis, is involved in the formation of 8-amino-3,8-dideoxy-α-D-manno-octulosonate, an aminated form of Kdo found in lipopolysaccharides of members of the Shewanella genus. cf. EC 2.6.1.109, 8-amino-3,8-dideoxy-α-D-manno-octulosonate transaminase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Gattis, S.G., Chung, H.S., Trent, M.S. and Raetz, C.R. The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis. J. Biol. Chem. 288 (2013) 9216–9225. [DOI] [PMID: 23413030]

[EC 1.1.3.48 created 2015]