The Enzyme Database

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Accepted name: D-mannitol oxidase
Reaction: D-mannitol + O2 = D-mannose + H2O2
Other name(s): mannitol oxidase; D-arabitol oxidase
Systematic name: mannitol:oxygen oxidoreductase (cyclizing)
Comments: Also catalyses the oxidation of D-arabinitol and, to a lesser extent, D-glucitol (sorbitol), whereas L-arabinitol is not a good substrate. The enzyme from the snails Helix aspersa and Arion ater is found in a specialised tubular organelle that has been termed the mannosome.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 73562-29-5
1.  Vorhaben, J.E., Scott, J.F., Smith, D.D. and Campbell, J.W. Mannitol oxidase: partial purification and characterisation of the membrane-bound enzyme from the snail Helix aspersa. Int. J. Biochem. 18 (1986) 337–344. [PMID: 3519307]
2.  Malik, Z., Jones, C.J.P. and Connock, M.J. Assay and subcellular localization of H2O2 generating mannitol oxidase in the terrestrial slug Arion ater. J. Exp. Zool. 242 (1987) 9–15.
3.  Large, A.T., Jones, C.J.P. and Connock, M.J. The association of mannitol oxidase with a distinct organelle in the digestive gland of the terrestrial slug Arion ater. Protoplasma 175 (1993) 93–101.
4.  Lobo-da-Cunha, A., Amaral-de-Carvalho, D., Oliveira, E., Alves, A., Costa, V. and Calado, G. Mannitol oxidase and polyol dehydrogenases in the digestive gland of gastropods: Correlations with phylogeny and diet. PLoS One 13:e0193078 (2018). [PMID: 29529078]
[EC created 2001]

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