ExplorEnz: EC 1.1.2.10

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1.1.2.10

Accepted name:

lanthanide-dependent methanol dehydrogenase

Reaction:

methanol + 2 oxidized cytochrome c_L = formaldehyde + 2 reduced cytochrome c_L

Other name(s):

XoxF; XoxF-MDH; Ce-MDH; La³⁺-dependent MDH; Ce³⁺-induced methanol dehydrogenase; cerium dependent MDH

Systematic name:

methanol:cytochrome c_L oxidoreductase

Comments:

Isolated from the bacterium Methylacidiphilum fumariolicum and many Methylobacterium species. Requires La³⁺, Ce³⁺, Pr³⁺ or Nd³⁺. The higher lanthanides show decreasing activity with Sm³⁺, Eu³⁺ and Gd³⁺. The lanthanide is coordinated by the enzyme and pyrroloquinoline quinone. Shows little activity with Ca²⁺, the required cofactor of EC 1.1.2.7, methanol dehydrogenase (cytochrome c).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Hibi, Y., Asai, K., Arafuka, H., Hamajima, M., Iwama, T. and Kawai, K. Molecular structure of La³⁺-induced methanol dehydrogenase-like protein in Methylobacterium radiotolerans. J. Biosci. Bioeng. 111 (2011) 547–549. [PMID: 21256798]
2.	Nakagawa, T., Mitsui, R., Tani, A., Sasa, K., Tashiro, S., Iwama, T., Hayakawa, T. and Kawai, K. A catalytic role of XoxF1 as La³⁺-dependent methanol dehydrogenase in Methylobacterium extorquens strain AM1. PLoS One 7:e50480 (2012). [PMID: 23209751]
3.	Pol, A., Barends, T.R., Dietl, A., Khadem, A.F., Eygensteyn, J., Jetten, M.S. and Op den Camp, H.J. Rare earth metals are essential for methanotrophic life in volcanic mudpots. Environ. Microbiol. 16 (2014) 255–264. [PMID: 24034209]
4.	Bogart, J.A., Lewis, A.J. and Schelter, E.J. DFT study of the active site of the XoxF-type natural, cerium-dependent methanol dehydrogenase enzyme. Chemistry Eur. J. 21 (2015) 1743–1748. [PMID: 25421364]
5.	Prejano, M., Marino, T. and Russo, N. How can methanol dehydrogenase from Methylacidiphilum fumariolicum work with the alien Ce(III) ion in the active center? A theoretical study. Chemistry 23 (2017) 8652–8657. [PMID: 28488399]
6.	Masuda, S., Suzuki, Y., Fujitani, Y., Mitsui, R., Nakagawa, T., Shintani, M. and Tani, A. Lanthanide-dependent regulation of methylotrophy in Methylobacterium aquaticum strain 22A. mSphere 3 (2018) e00462. [PMID: 29404411]

[EC 1.1.2.10 created 2019]