The Enzyme Database

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Accepted name: methylglyoxal reductase (NADH)
Reaction: (R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+
Glossary: 2-oxopropanal = methylglyoxal
Other name(s): methylglyoxal reductase; D-lactaldehyde dehydrogenase; methylglyoxal reductase (NADH-dependent)
Systematic name: (R)-lactaldehyde:NAD+ oxidoreductase
Comments: This mammalian enzyme differs from the yeast enzyme, EC, methylglyoxal reductase (NADPH), by its cosubstrate requirement, reaction direction, and enantiomeric preference.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37250-16-1
1.  Ting, S.-M., Miller, O.N. and Sellinger, O.Z. The metabolism of lactaldehyde. VII. The oxidation of D-lactaldehyde in rat liver. Biochim. Biophys. Acta 97 (1965) 407–415. [DOI] [PMID: 14323585]
2.  Ray, M. and Ray, S. Purification and partial characterization of a methylglyoxal reductase from goat liver. Biochim. Biophys. Acta 802 (1984) 119–127. [DOI] [PMID: 6386056]
[EC created 1972, modified 2005, modified 2013]

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