| EC |
1.1.1.437 |
| Accepted name: |
5-dehydrofumagillol 5-reductase |
| Reaction: |
fumagillol + NADP+ = 5-dehydrofumagillol + NADPH + H+ |
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For diagram of reaction, click here |
| Glossary: |
fumagillol = (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-ol |
| Other name(s): |
af490 (gene name); Fma-KR |
| Systematic name: |
fumagillol:NADP+ 5-oxidoreductase |
| Comments: |
The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin. It is a partial polyketide synthase (PKS) consisting of only a dehydratase (DH) and a ketoreductase (KR) domain. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Lin, H.C., Tsunematsu, Y., Dhingra, S., Xu, W., Fukutomi, M., Chooi, Y.H., Cane, D.E., Calvo, A.M., Watanabe, K. and Tang, Y. Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. J. Am. Chem. Soc. 136 (2014) 4426–4436. [DOI] [PMID: 24568283] |
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| [EC 1.1.1.437 created 2022] |
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