| EC |
1.1.1.436 |
| Accepted name: |
lactate dehydrogenase (NAD+,ferredoxin) |
| Reaction: |
lactate + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = pyruvate + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster |
| Other name(s): |
electron bifurcating LDH/Etf complex |
| Systematic name: |
lactate:NAD+,ferredoxin oxidoreductase |
| Comments: |
The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Weghoff, M.C., Bertsch, J. and Muller, V. A novel mode of lactate metabolism in strictly anaerobic bacteria. Environ. Microbiol. 17 (2015) 670–677. [DOI] [PMID: 24762045] |
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| [EC 1.1.1.436 created 2015 as EC 1.3.1.110, transferred 2022 to EC 1.1.1.436] |
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