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Your query returned 1 entry. Printable version
EC | 1.1.1.42 | ||||||||||||||||||
Accepted name: | isocitrate dehydrogenase (NADP+) | ||||||||||||||||||
Reaction: | isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+ (overall reaction) (1a) isocitrate + NADP+ = oxalosuccinate + NADPH + H+ (1b) oxalosuccinate = 2-oxoglutarate + CO2 |
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For diagram of the citric-acid cycle, click here | |||||||||||||||||||
Glossary: | isocitrate = (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate (previously known as threo-Ds-isocitrate) oxalosuccinate = 1-oxopropane-1,2,3-tricarboxylate |
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Other name(s): | oxalosuccinate decarboxylase; oxalsuccinic decarboxylase; isocitrate (NADP) dehydrogenase; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific isocitrate dehydrogenase; NADP-linked isocitrate dehydrogenase; NADP-dependent isocitrate dehydrogenase; NADP isocitric dehydrogenase; isocitrate dehydrogenase (NADP-dependent); NADP-dependent isocitric dehydrogenase; triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase; NADP+-linked isocitrate dehydrogenase; IDH (ambiguous); dual-cofactor-specific isocitrate dehydrogenase; NADP+-ICDH; NADP+-IDH; IDP; IDP1; IDP2; IDP3 | ||||||||||||||||||
Systematic name: | isocitrate:NADP+ oxidoreductase (decarboxylating) | ||||||||||||||||||
Comments: | Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [6]. The enzyme from some species can also use NAD+ but much more slowly [6,7]. | ||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9028-48-2 | ||||||||||||||||||
References: |
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