The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: L-serine 3-dehydrogenase (NAD+)
Reaction: L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH + H+ (overall reaction)
(1a) L-serine + NAD+ = 2-aminomalonate semialdehyde + NADH + H+
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous)
Other name(s): NAD+-dependent L-serine dehydrogenase
Systematic name: L-serine:NAD+ 3-oxidoreductase
Comments: The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC, serine 3-dehydrogenase (NADP+)].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Tchigvintsev, A., Singer, A., Brown, G., Flick, R., Evdokimova, E., Tan, K., Gonzalez, C.F., Savchenko, A. and Yakunin, A.F. Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD+-dependent L-serine dehydrogenase. J. Biol. Chem. 287 (2012) 1874–1883. [DOI] [PMID: 22128181]
[EC created 2015]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald