ExplorEnz: EC 1.1.1.385

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1.1.1.385

Accepted name:

dihydroanticapsin dehydrogenase

Reaction:

L-dihydroanticapsin + NAD⁺ = L-anticapsin + NADH + H⁺

For diagram of bacilysin biosynthesis, click here

Glossary:

L-dihydroanticapsin = 3-[(1R,2S,5R,6S)-5-hydroxy-7-oxabicyclo[4.1.0]hept-2-yl]-L-alanine
L-anticapsin = 3-[(1R,2S,6R)-5-oxo-7-oxabicyclo[4.1.0]hept-2-yl]-L-alanine

Other name(s):

BacC; ywfD (gene name)

Systematic name:

L-dihydroanticapsin:NAD⁺ oxidoreductase

Comments:

The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Parker, J.B. and Walsh, C.T. Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin. Biochemistry 52 (2013) 889–901. [DOI] [PMID: 23317005]

[EC 1.1.1.385 created 2015]