| EC |
1.1.1.350 |
| Accepted name: |
ureidoglycolate dehydrogenase (NAD+) |
| Reaction: |
(S)-ureidoglycolate + NAD+ = N-carbamoyl-2-oxoglycine + NADH + H+ |
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For diagram of AMP catabolism, click here |
| Systematic name: |
(S)-ureidoglycolate:NAD+ oxidoreductase |
| Comments: |
Involved in catabolism of purines. The enzyme from the bacterium Escherichia coli is specific for NAD+ [2]. cf. EC 1.1.1.154, ureidoglycolate dehydrogenase [NAD(P)+]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Cusa, E., Obradors, N., Baldoma, L., Badia, J. and Aguilar, J. Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli. J. Bacteriol. 181 (1999) 7479–7484. [PMID: 10601204] |
| 2. |
Kim, M.I., Shin, I., Cho, S., Lee, J. and Rhee, S. Structural and functional insights into (S)-ureidoglycolate dehydrogenase, a metabolic branch point enzyme in nitrogen utilization. PLoS One 7:e52066 (2012). [DOI] [PMID: 23284870] |
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| [EC 1.1.1.350 created 2013] |
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