ExplorEnz: EC 1.1.1.340

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1.1.1.340

Accepted name:

1-deoxy-11β-hydroxypentalenate dehydrogenase

Reaction:

1-deoxy-11β-hydroxypentalenate + NAD⁺ = 1-deoxy-11-oxopentalenate + NADH + H⁺

For diagram of pentalenolactone biosynthesis, click here

Glossary:

1-deoxy-11β-hydroxypentalenate = (1S,2R,3aR,5aS,8aR)-2-hydroxy-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate
1-deoxy-11-oxopentalenate = (1S,3aR,5aS)-1,7,7-trimethyl-2-oxo-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate

Other name(s):

1-deoxy-11β-hydroxypentalenic acid dehydrogenase; ptlF (gene name); penF (gene name)

Systematic name:

1-deoxy-11β-hydroxypentalenate:NAD⁺ oxidoreductase

Comments:

Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

You, Z., Omura, S., Ikeda, H. and Cane, D.E. Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate. Arch. Biochem. Biophys. 459 (2007) 233–240. [DOI] [PMID: 17178094]

[EC 1.1.1.340 created 2012]