ExplorEnz: EC 1.1.1.339

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1.1.1.339

Accepted name:

dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD⁺)

Reaction:

dTDP-6-deoxy-β-L-talose + NAD⁺ = dTDP-4-dehydro-β-L-rhamnose + NADH + H⁺

Glossary:

dTDP-4-dehydro-β-L-rhamnose = dTDP-4-dehydro-6-deoxy-β-L-mannose
dTDP-6-deoxy-β-L-talose = dTDP-β-L-pneumose

Other name(s):

tll (gene name)

Systematic name:

dTDP-6-deoxy-β-L-talose:NAD⁺ 4-oxidoreductase

Comments:

The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP⁺.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Nakano, Y., Suzuki, N., Yoshida, Y., Nezu, T., Yamashita, Y. and Koga, T. Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans. J. Biol. Chem. 275 (2000) 6806–6812. [DOI] [PMID: 10702238]

[EC 1.1.1.339 created 2012]