ExplorEnz: EC 1.1.1.331

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1.1.1.331

Accepted name:

secoisolariciresinol dehydrogenase

Reaction:

(–)-secoisolariciresinol + 2 NAD⁺ = (–)-matairesinol + 2 NADH + 2 H⁺

For diagram of matairesinol biosynthesis, click here

Systematic name:

(–)-secoisolariciresinol:NAD⁺ oxidoreductase

Comments:

Isolated from the plants Forsythia intermedia [1] and Podophyllum peltatum [1-3]. An intermediate lactol is detected in vitro.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B. and Lewis, N.G. Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection. J. Biol. Chem. 276 (2001) 12614–12623. [DOI] [PMID: 11278426]
2.	Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G. and Kang, C. Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans. J. Biol. Chem. 280 (2005) 12917–12926. [DOI] [PMID: 15653677]
3.	Moinuddin, S.G., Youn, B., Bedgar, D.L., Costa, M.A., Helms, G.L., Kang, C., Davin, L.B. and Lewis, N.G. Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum. Org. Biomol. Chem. 4 (2006) 808–816. [DOI] [PMID: 16493463]

[EC 1.1.1.331 created 2012]