The Enzyme Database

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Accepted name: phosphonoacetaldehyde reductase (NADH)
Reaction: 2-hydroxyethylphosphonate + NAD+ = phosphonoacetaldehyde + NADH + H+
For diagram of phosphonate metabolism, click here
Other name(s): PhpC
Systematic name: 2-hydroxyethylphosphonate:NAD+ oxidoreductase
Comments: The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate. The preferred cofactor is NADH, lower activity with NADPH [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Blodgett, J.A., Thomas, P.M., Li, G., Velasquez, J.E., van der Donk, W.A., Kelleher, N.L. and Metcalf, W.W. Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat. Chem. Biol. 3 (2007) 480–485. [DOI] [PMID: 17632514]
[EC created 2011]

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