| EC |
1.1.1.309 |
| Accepted name: |
phosphonoacetaldehyde reductase (NADH) |
| Reaction: |
2-hydroxyethylphosphonate + NAD+ = phosphonoacetaldehyde + NADH + H+ |
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For diagram of phosphonate metabolism, click here |
| Other name(s): |
PhpC |
| Systematic name: |
2-hydroxyethylphosphonate:NAD+ oxidoreductase |
| Comments: |
The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate. The preferred cofactor is NADH, lower activity with NADPH [1]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Blodgett, J.A., Thomas, P.M., Li, G., Velasquez, J.E., van der Donk, W.A., Kelleher, N.L. and Metcalf, W.W. Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat. Chem. Biol. 3 (2007) 480–485. [DOI] [PMID: 17632514] |
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| [EC 1.1.1.309 created 2011] |
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