ExplorEnz: EC 1.1.1.296

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1.1.1.296

Accepted name:

dihydrocarveol dehydrogenase

Reaction:

menth-8-en-2-ol + NAD⁺ = menth-8-en-2-one + NADH + H⁺

For diagram of (–)-carvone catabolism, click here

Glossary:

(+)-dihydrocarveol = (1S,2S,4S)-menth-8-en-2-ol
(+)-isodihydrocarveol = (1S,2S,4R)-menth-8-en-2-ol
(+)-neoisodihydrocarveol = (1S,2R,4R)-menth-8-en-2-ol
(–)-dihydrocarvone = (1S,4S)-menth-8-en-2-one
(+)-isodihydrocarvone = (1S,4R)-menth-8-en-2-one

Other name(s):

carveol dehydrogenase (ambiguous)

Systematic name:

menth-8-en-2-ol:NAD⁺ oxidoreductase

Comments:

This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (–)-isodihydrocarveol.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	van der Werf, M.J. and Boot, A.M. Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14. Microbiology 146 (2000) 1129–1141. [DOI] [PMID: 10832640]

[EC 1.1.1.296 created 2008]