ExplorEnz: EC 1.1.1.287

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1.1.1.287

Accepted name:

D-arabinitol dehydrogenase (NADP⁺)

Reaction:

(1) D-arabinitol + NADP⁺ = D-xylulose + NADPH + H⁺
(2) D-arabinitol + NADP⁺ = D-ribulose + NADPH + H⁺

Other name(s):

NADP⁺-dependent D-arabitol dehydrogenase; ARD1p; D-arabitol dehydrogenase 1

Systematic name:

D-arabinitol:NADP⁺ oxidoreductase

Comments:

The enzyme from the rust fungus Uromyces fabae can use D-arabinitol and D-mannitol as substrates in the forward direction and D-xylulose, D-ribulose and, to a lesser extent, D-fructose as substrates in the reverse direction. This enzyme carries out the reactions of both EC 1.1.1.11, D-arabinitol 4-dehydrogenase and EC 1.1.1.250, D-arabinitol 2-dehydrogenase, but unlike them, uses NADP⁺ rather than NAD⁺ as cofactor. D-Arabinitol is capable of quenching reactive oxygen species involved in defense reactions of the host plant.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Link, T., Lohaus, G., Heiser, I., Mendgen, K., Hahn, M. and Voegele, R.T. Characterization of a novel NADP⁺-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae. Biochem. J. 389 (2005) 289–295. [DOI] [PMID: 15796718]

[EC 1.1.1.287 created 2005]