ExplorEnz: EC 1.1.1.276

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1.1.1.276

Accepted name:

serine 3-dehydrogenase (NADP⁺)

Reaction:

L-serine + NADP⁺ = 2-aminoacetaldehyde + CO₂ + NADPH + H⁺ (overall reaction)
(1a) L-serine + NADP⁺ = 2-aminomalonate semialdehyde + NADPH + H⁺
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO₂ (spontaneous)

Other name(s):

serine 3-dehydrogenase

Systematic name:

L-serine:NADP⁺ 3-oxidoreductase

Comments:

NAD⁺ cannot replace NADP⁺ [cf. EC 1.1.1.387, serine 3-dehydrogenase (NAD⁺)].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9038-55-5

References:

1.	Fujisawa, H., Nagata, S., Chowdhury, E.K., Matsumoto, M. and Misono, H. Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens. Biosci. Biotechnol. Biochem. 66 (2002) 1137–1139. [PMID: 12092831]
2.	Chowdhury, E.K., Higuchi, K., Nagata, S. and Misono, H. A novel NADP⁺ dependent serine dehydrogenase from Agrobacterium tumefaciens. Biosci. Biotechnol. Biochem. 61 (1997) 152–157. [PMID: 9028042]

[EC 1.1.1.276 created 2003, modified 2015]