The Enzyme Database

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Accepted name: mannitol dehydrogenase
Reaction: D-mannitol + NAD+ = D-mannose + NADH + H+
Other name(s): MTD; NAD-dependent mannitol dehydrogenase
Systematic name: mannitol:NAD+ 1-oxidoreductase
Comments: The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation. The enzyme is specific for NAD+ and does not use NADP+.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 144941-29-7
1.  Stoop, J.M.H. and Pharr, D.M. Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots. Arch. Biochem. Biophys. 298 (1992) 612–619. [DOI] [PMID: 1416989]
2.  Stoop, J.M.H., Williamson, J.D., Conkling, M.A. and Pharr, D.M. Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures. Plant Physiol. (1995) 108 (1995) 1219–1225. [PMID: 7630943]
3.  Williamson, J.D., Stoop, J.M.H., Massel, M.O., Conkling, M.A. and Pharr, D.M. Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3. Proc. Natl. Acad. Sci. USA 92 (1995) 7148–7152. [DOI] [PMID: 7638158]
4.  Stoop, J.M.H., Chilton, W.S. and Pharr, D.M. Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery. Phytochemistry 43 (1996) 1145–1150.
[EC created 2000]

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