The Enzyme Database

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Accepted name: hydroxyphenylpyruvate reductase
Reaction: (1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+
(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+
For diagram of 4-hydroxyphenylpyruvate metabolites, click here and for diagram of rosmarinate biosynthesis, click here
Other name(s): HPPR
Systematic name: (R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase
Comments: The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 117590-77-9
1.  Petersen, M. and Alfermann, A.W. Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase. Z. Naturforsch. C: Biosci. 43 (1988) 501–504.
2.  Kim, K.H., Janiak, V. and Petersen, M. Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei. Plant Mol. Biol. 54 (2004) 311–323. [PMID: 15284489]
3.  Kim, Y.B., Uddina, M.R., Kim, Y., Park, C.G. and Park, S.U. Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria baicalensis. Nat. Prod. Commun. 9 (2014) 1311–1314. [PMID: 25918800]
4.  Wang, G.Q., Chen, J.F., Yi, B., Tan, H.X., Zhang, L. and Chen, W.S. HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza. Chin J Nat Med 15 (2017) 917–927. [PMID: 29329649]
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