ExplorEnz: EC 1.1.1.226

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1.1.1.226

Accepted name:

trans-4-hydroxycyclohexanecarboxylate dehydrogenase

Reaction:

trans-4-hydroxycyclohexane-1-carboxylate + NAD⁺ = 4-oxocyclohexane-1-carboxylate + NADH + H⁺

Glossary:

trans-4-hydroxycyclohexane-1-carboxylate = trans-4-hydroxycyclohexanecarboxylate
4-oxocyclohexane-1-carboxylate = 4-oxocyclohexanecarboxylate

Other name(s):

4-hydroxycyclohexanecarboxylate dehydrogenase (ambiguous); chcB1 (gene name)

Systematic name:

trans-4-hydroxycyclohexane-1-carboxylate:NAD⁺ 4-oxidoreductase

Comments:

The enzyme from Corynebacterium cyclohexanicum is highly specific for the trans-4-hydroxy derivative. cf. EC 1.1.1.438, cis-4-hydroxycyclohexanecarboxylate dehydrogenase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 67272-36-0

References:

1.	Obata, H., Uebayashi, M. and Kaneda, T. Purification and properties of 4-hydroxycyclohexanecarboxylate dehydrogenase from Corynebacterium cyclohexanicum. Eur. J. Biochem. 174 (1988) 451–458. [DOI] [PMID: 3292236]
2.	Yamamoto, T., Hasegawa, Y., Lau, P.CK. and Iwaki, H. Identification and characterization of a chc gene cluster responsible for the aromatization pathway of cyclohexanecarboxylate degradation in Sinomonas cyclohexanicum ATCC 51369. J. Biosci. Bioeng. 132 (2021) 621–629. [DOI] [PMID: 34583900]

[EC 1.1.1.226 created 1990, modified 2024]