| EC |
1.1.1.22 |
| Accepted name: |
UDP-glucose 6-dehydrogenase |
| Reaction: |
UDP-α-D-glucose + 2 NAD+ + H2O = UDP-α-D-glucuronate + 2 NADH + 2 H+ |
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For diagram of the biosynthesis of UDP-α-D-glucose, UDP-α-D-galactose and UDP-α-D-glucuronate, click here |
| Other name(s): |
UDP-glucose dehydrogenase; uridine diphosphoglucose dehydrogenase; UDPG dehydrogenase; UDPG:NAD oxidoreductase; UDP-α-D-glucose:NAD oxidoreductase; UDP-glucose:NAD+ oxidoreductase; uridine diphosphate glucose dehydrogenase; UDP-D-glucose dehydrogenase; uridine diphosphate D-glucose dehydrogenase |
| Systematic name: |
UDP-α-D-glucose:NAD+ 6-oxidoreductase |
| Comments: |
Also acts on UDP-α-D-2-deoxyglucose. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9028-26-6 |
| References: |
| 1. |
Druzhinina, T.N., Kusov, Y.Y., Shibaev, V.N., Kochetkov, N.K., Biely, P., Kucar, S. and Bauer, S. Uridine diphosphate 2-deoxyglucose. Chemical synthesis, enzymic oxidation and epimerization. Biochim. Biophys. Acta 381 (1975) 301–307. [DOI] [PMID: 1091296] |
| 2. |
Maxwell, E.S., Kalckar, H.M. and Strominger, J.L. Some properties of uridine diphosphoglucose dehydrogenase. Arch. Biochem. Biophys. 65 (1956) 2–10. [DOI] [PMID: 13373402] |
| 3. |
Strominger, J.L. and Mapson, L.W. Uridine diphosphoglucose dehydrogenase of pea seedlings. Biochem. J. 66 (1957) 567–572. [PMID: 13459898] |
| 4. |
Strominger, J.L., Maxwell, E.S., Axelrod, J. and Kalckar, H.M. Enzymatic formation of uridine diphosphogluconic acid. J. Biol. Chem. 224 (1957) 79–90. [PMID: 13398389] |
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| [EC 1.1.1.22 created 1961] |
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