The Enzyme Database

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Accepted name: long-chain-3-hydroxyacyl-CoA dehydrogenase
Reaction: a long-chain (S)-3-hydroxyacyl-CoA + NAD+ = a long-chain 3-oxoacyl-CoA + NADH + H+
Glossary: a long-chain acyl-CoA = an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms.
Other name(s): β-hydroxyacyl-CoA dehydrogenase; long-chain 3-hydroxyacyl coenzyme A dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase; LCHAD
Systematic name: long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Comments: This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 3-hydroxyacyl-CoA dehydrogenase).
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 84177-52-6
1.  El-Fakhri, M. and Middleton, B. The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria. Biochim. Biophys. Acta 713 (1982) 270–279. [DOI] [PMID: 7150615]
[EC created 1986]

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